Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia
| Autor: | Hiroki Ishiguro, Katsuya Ota, Tadao Arinami, Yoshiro Okubo, Michio Toru, Hideo Hamaguchi, Junichi Aoki, Haruo Shibuya, Atsushi Iwawaki, Hiromitsu Shimizu, Akeo Kurumaji, Tsuyuka Ohtsuki, Masanari Itokawa |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Rimcazole Adolescent Proline Genetic Linkage Glutamine Sigma receptor Biology Polymerase Chain Reaction chemistry.chemical_compound Gene Frequency Japan Genetic linkage Internal medicine Haloperidol medicine Humans Receptors sigma Receptor Allele frequency Aged DNA Primers Genetics Aged 80 and over Polymorphism Genetic General Neuroscience Haplotype Middle Aged medicine.disease Endocrinology chemistry Mutation Schizophrenia Female medicine.drug |
| Zdroj: | Neuroscience letters. 257(1) |
| ISSN: | 0304-3940 |
| Popis: | Several antipsychotic agents such as haloperidol and rimcazole are known to bind to sigma receptors with high affinity, and evidence for a potential link between sigma receptors and the etiology of schizophrenia has been reported. The present study was conducted to systematically search for nucleotide variants of the type 1 sigma receptor gene in 48 schizophrenics. Two polymorphisms were found: GC-241-240TT in the 5' flanking region and Gln2Pro. These two polymorphisms were in nearly complete linkage disequilibrium with each other. The Pro2 variant of the Gln2Pro polymorphism changes the endoplasmic reticulum retention signal motif. These polymorphisms were examined in an extended sample of schizophrenics (n = 308) and controls (n = 433) and a significant association between the presence of the TT/Pro2 haplotype and schizophrenia was observed (odds ratio = 1.27, P = 0.04). |
| Databáze: | OpenAIRE |
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