A survey of electrokinetically-driven microfluidics for cancer cells manipulation
| Autor: | Fabian O. Romero-Soto, Sergio O. Martinez-Chapa, Roberto C. Gallo-Villanueva, Maria I. Polanco-Oliva, Victor H. Perez-Gonzalez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Electrophoresis medicine.medical_specialty Clinical Biochemistry Microfluidics Early detection 02 engineering and technology 01 natural sciences Biochemistry Analytical Chemistry Metastasis Internal medicine Lab-On-A-Chip Devices Neoplasms medicine Biomarkers Tumor Tumor Cells Cultured Humans Liquid biopsy business.industry 010401 analytical chemistry Cancer Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology medicine.disease Neoplastic Cells Circulating 0104 chemical sciences Cancer cell Electronic instrumentation Cancer biomarkers 0210 nano-technology business |
| Zdroj: | Electrophoresis6 References. 42(5) |
| ISSN: | 1522-2683 |
| Popis: | Cancer is one of the leading causes of annual deaths worldwide, accounting for nearly 10 million deaths each year. Metastasis, the process by which cancer spreads across the patient's body, is the main cause of death in cancer patients. Because the rising trend observed in statistics of new cancer cases and cancer-related deaths does not allow for an optimistic viewpoint on the future-in relation to this terrible disease-the scientific community has sought methods to enable early detection of cancer and prevent the apparition of metastatic tumors. One such method is known as liquid biopsy, wherein a sample is taken from a bodily fluid and analyzed for the presence of CTCs or other cancer biomarkers (e.g., growth factors). With this objective, interest is growing by year in electrokinetically-driven microfluidics applied for the concentration, capture, filtration, transportation, and characterization of CTCs. Electrokinetic techniques-electrophoresis, dielectrophoresis, electrorotation, and electrothermal and EOF-have great potential for miniaturization and integration with electronic instrumentation for the development of point-of-care devices, which can become a tool for early cancer diagnostics and for the design of personalized therapeutics. In this contribution, we review the state of the art of electrokinetically-driven microfluidics for cancer cells manipulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text