Longitudinal Analysis of Self-Reported Symptoms, Behavioral Measures, and Event-Related Potential Components of a Cued Go/NoGo Task in Adults With Attention-Deficit/Hyperactivity Disorder and Controls
| Autor: | Marionna Münger, Silvano Sele, Gian Candrian, Johannes Kasper, Hossam Abdel-Rehim, Dominique Eich-Höchli, Andreas Müller, Lutz Jäncke |
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| Přispěvatelé: | University of Zurich, Münger, Marionna, Jäncke, Lutz |
| Rok vydání: | 2021 |
| Předmět: |
reliability
10093 Institute of Psychology longitudinal study Go/NoGo task Neurosciences. Biological psychiatry. Neuropsychiatry UFSP13-4 Dynamics of Healthy Aging attention-deficit/hyperactivity disorder (ADHD) behavioral disciplines and activities 3206 Neuropsychology and Physiological Psychology Behavioral Neuroscience Psychiatry and Mental health 2738 Psychiatry and Mental Health Neuropsychology and Physiological Psychology Neurology 2808 Neurology 2802 Behavioral Neuroscience event-related potentials (ERPs) adults 150 Psychology 2803 Biological Psychiatry Biological Psychiatry RC321-571 |
| Zdroj: | Frontiers in Human Neuroscience, Vol 16 (2022) |
| ISSN: | 1662-5161 |
| Popis: | This study characterizes a large sample of adults with attention-deficit/hyperactivity disorder (ADHD) and healthy controls regarding their task performance and neurophysiology; cross-sectionally and longitudinally. Self-reported symptoms, behavioral measures, and event-related potentials from a classical cued Go/NoGo task were used to outline the symptom burden, executive function deficits and neurophysiological features, and the associations between these domains. The study participants (N = 210 ADHD, N = 158 controls, age: 18–62 years) were assessed five (ADHD) or three (controls) times over two years. We describe cross-sectional and longitudinal group differences, and associations between symptom burden, and behavioral and event-related potential (ERP) components variables by latent growth curve models, including random slopes and intercepts. The ADHD group showed increased reaction time variability, increased commission and omission errors, and attenuated cueP3, CNV, N2d, and P3d amplitudes. We observed a decrease in self-reported symptoms in the ADHD group over the two years. The behavioral measures (reaction time variability, number of omission, and commission errors) did not change over time, whereas the cueP3, P3d, and N2d amplitude attenuated in both groups. There was no evidence for a robust association between symptom burden and behavioral or ERP measures. The changes in the ERP components with stable task performance, potentially indicate more efficient neuronal processing over the two years. Whether the lack of association between symptom burden and behavioral or ERP measures might be due to the low reliability of the ADHD assessment criteria, or the inappropriateness of the objective measures cannot be inferred. |
| Databáze: | OpenAIRE |
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