Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria
| Autor: | Alan Brockman, François Nosten, Ric N. Price, Am Kham, Tan Chongsuphajaisiddhi, Christine Luxemburger, Nicholas J. White |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Time Factors Adolescent Administration Oral Artesunate Myanmar Drug resistance Pharmacology Antimalarials chemistry.chemical_compound Humans Medicine Artemether Malaria Falciparum Artemisinin Child Adverse effect biology business.industry Mefloquine Public Health Environmental and Occupational Health Plasmodium falciparum General Medicine Thailand medicine.disease biology.organism_classification Artemisinins Drug Resistance Multiple Treatment Outcome Infectious Diseases chemistry Child Preschool Drug Therapy Combination Female Parasitology business Sesquiterpenes Malaria medicine.drug |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 89:523-527 |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/0035-9203(95)90094-2 |
| Popis: | To compare the therapeutic efficacy of oral artesunate and artemether in combination with mefloquine for the treatment of multidrug resistant malaria, a trial was conducted in 540 adults and children on the Thai-Myanmar border. Three regimens were compared: artesunate (4 mg/kg/d for 3 d), artemether (4 mg/kg/d for 3 d), both in combination with mefloquine (25 mg/kg), and a single dose of mefloquine (25 mg/kg). The artesunate and artemether regimens gave very similar clinical and parasitological responses, and were both very well tolerated. There was no significant adverse effect attributable to the artemisinin derivatives. Fever and parasite clearance times with mefloquine alone were significantly longer (P < 0.001). After adjusting for reinfections the failure rates were 13.9% for the artesunate combination, 12.3% for the artemether combination and 49.2% for mefloquine alone (P < 0.0001; relative risk 3.8 [95% confidence interval 2.6-5.4]). Mefloquine should no longer be used alone for the treatment of multidrug resistant falciparum malaria in this area. Three-day combination regimens with artesunate or artemether are well tolerated and more effective. |
| Databáze: | OpenAIRE |
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