Serum vascular adhesion protein-1 level is higher in smokers than non-smokers

Autor:	Mao-Shin Lin, David Smith, Lee-Ming Chuang, Jani Vanio, Jung-Nan Wei, Yi-Chia Wang, Cyue-Huei Hua, Shyang-Rong Shih, Hung-Yuan Li
Rok vydání:	2013
Předmět:	Adult Male Aging medicine.medical_specialty Waist Physiology Epidemiology Cross-sectional study medicine.medical_treatment Fluoroimmunoassay Taiwan Renal function Pathogenesis Young Adult Neoplasms Internal medicine Genetics medicine Humans Young adult Aged Aged 80 and over business.industry Smoking Public Health Environmental and Occupational Health Cancer Middle Aged Atherosclerosis medicine.disease respiratory tract diseases Surgery Cross-Sectional Studies Endocrinology Biomarker (medicine) Smoking cessation Female Amine Oxidase (Copper-Containing) business Cell Adhesion Molecules
Zdroj:	Annals of Human Biology. 40:413-418
ISSN:	1464-5033 0301-4460
DOI:	10.3109/03014460.2013.788679
Popis:	Semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) is involved in the pathogenesis of both atherosclerosis and cancer. Because chemical components and metabolites of cigarettes are deaminated by SSAO, the relationship between smoking and serum SSAO/VAP-1 was studied in humans.A total of 451 non-diabetic and normoalbuminuric Han Chinese subjects were recruited to participate in this study. Smoking history was obtained by using a questionnaire and those who smoked more than 100 cigarettes during a 6-month period were considered smokers. Serum VAP-1 concentration was measured by time-resolved immunofluorometric assay. Age, gender, waist circumference and estimated glomerular filtration rate (GFR) were adjusted in different statistical models.Smokers were mainly male (85.7% versus 26.3%) and were more obese than non-smokers (p 0.05). Subjects with higher serum VAP-1 concentrations were older (p 0.001) and tended to have larger waist circumferences and lower estimated GFR. Serum VAP-1 concentration was higher in smokers than in non-smokers (p 0.05) after adjusting for age, gender, waist circumference, estimated GFR, liver biochemistry and lipid profile.Cigarette smoking is associated with elevated serum VAP-1 concentration. Whether VAP-1 and its SSAO activity link the relationship between cigarette smoking, atherosclerosis and cancer requires further investigation.
Databáze:	OpenAIRE
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