The liver, a functionalized vascular structure
Autor: | Sylvie Lorente, Mathieu Hautefeuille, Aczel Sánchez-Cedillo |
---|---|
Přispěvatelé: | Laboratoire Matériaux et Durabilité des constructions (LMDC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
[SDV]Life Sciences [q-bio]
lcsh:Medicine Human metabolism Hepatic Veins Article Engineering Hepatic Artery medicine Animals Humans Vascular structure Liver blood flow lcsh:Science Multidisciplinary Constructal law Chemistry lcsh:R Dendritic Cells Blood flow Models Theoretical medicine.anatomical_structure Liver lcsh:Q Duct (anatomy) Design evolution Liver Circulation Artery Biomedical engineering |
Zdroj: | Scientific Reports Scientific Reports, 2020, 10 (1), pp.16194. ⟨10.1038/s41598-020-73208-8⟩ Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
ISSN: | 2045-2322 |
Popis: | The liver is not only the largest organ in the body but also the one playing one of the most important role in the human metabolism as it is in charge of transforming toxic substances in the body. Understanding the way its blood vasculature works is key. In this work we show that the challenge of predicting the hepatic multi-scale vascular network can be met thanks to the constructal law of design evolution. The work unveils the structure of the liver blood flow architecture as a combination of superimposed tree-shaped networks and porous system. We demonstrate that the dendritic nature of the hepatic artery, portal vein and hepatic vein can be predicted, together with their geometrical features (diameter ratio, duct length ratio) as the entire blood flow architectures follow the principle of equipartition of imperfections. At the smallest scale, the shape of the liver elemental systems—the lobules—is discovered, while their permeability is also predicted. The theory is compared with good agreement to anatomical data from the literature. |
Databáze: | OpenAIRE |
Externí odkaz: |