Renalase is removed by kidneys and during dialysis - excess related to CKD complications?
| Autor: | Jolanta Malyszko, Ewa Koc-Zorawska, Maciej Banach, Marcin Zorawski, Jacek S. Malyszko, Edyta Zbroch, Jacek Rysz, Piotr Kozminski |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urinary system Urology Diuresis Kidney Nephrectomy Renal Dialysis Internal medicine medicine Humans Renal Insufficiency Chronic Monoamine Oxidase Renalase Dialysis Pharmacology business.industry Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Cross-Sectional Studies Case-Control Studies Hemodialysis Cardiology and Cardiovascular Medicine business Kidney disease |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1875-6212 |
| Popis: | Background: The most common complications of chronic kidney disease (CKD) are hypertension and cardiovascular (CV) disorders. Renalase is produced and released by the kidney and also cardiomyocytes. Renalase deficiency was claimed to be responsible for hypertension and CV complication in CKD. There are contradictory data about serum renalase because of low activity and high levels revealed in hypertensive patients with CKD. We assessed serum renalase concentration in objects with CKD after one-side and both-side nephrectomy (on haemodialysis [HD]), or hemodiafiltration (HDF), in urine and ultrafiltrate in hemodialysis objects. We also evaluated the influence of hemodialysis sessions on renalase concentrations. Methods: The concentration of renalase in plasma, ultrafiltrate and urine of 100 hemodialysis patients was assessed by commercially accessible test. We evaluated renalase in 17 HDF objects and 24 healthy controls. Western Blot test was also used to assess renalase concentration. Results: Ultrafiltrate in hemodialysis objects contained renalase and there was no impact of dialysers' type (high-flux and low-flux). Renalase concentration of urine in control group was higher than in hemodialysis objects (n=60). The anuric group had higher renalase concentration comparing to those with remaining diuresis (p |
| Databáze: | OpenAIRE |
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