Extracellular vesicles as miRNA nano-shuttles : dual role in tumor progression
| Autor: | Simona Fontana, Pablo Reclusa Asiáin, Christian Rolfo, Simona Taverna, Aung Naing, Eloisa Jantus-Lewintre, Mahafarin Malarani, Francesco Passiglia, Shahanavaj Khan, Luis E. Raez, Marzia Pucci, Elena Duréndez Sáez |
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| Přispěvatelé: | Pucci, M., Reclusa Asiáin, P., Duréndez Sáez, E., Jantus-Lewintre, E., Malarani, M., Khan, S., Fontana, S., Naing, A., Passiglia, F., Raez, L., Rolfo, C., Taverna, S. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Angiogenic Switch Lung-Cancer BIOLOGIA CELULAR Messenger-RNAs Suppressor-Cells Dendritic cells Metastasis Liquid biopsies 03 medical and health sciences Extracellular Vesicles Immune system Settore BIO/13 - Biologia Applicata microRNA Medicine Humans Nanotechnology Pharmacology (medical) miRNA Myelogenous Leukemia-Cells Extracellular vesicles cancer cells Tumor microenvironment Exosome-Mediated transfer business.industry Cancer Proteins medicine.disease Micrornas MicroRNAs 030104 developmental biology Oncology Tumor progression Cancer cell Cancer research Disease Progression Human medicine Extracellular vesicle business Microvesicles |
| Zdroj: | Targeted oncology RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname Targeted Oncology r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia |
| ISSN: | 1776-2596 |
| Popis: | [EN] Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression. Elena Durendez has a predoctoral fellowship by Asociacion Espanola Contra el Cancer (AECC, Valencia, Spain). |
| Databáze: | OpenAIRE |
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