Morphologic, immunphenotypic and clinical discriminators between T-cell/histiocyterich large B-cell lymphoma and lymphocyte-predominant Hodgkin lymphoma
Autor: | Amr El Weshi, Mohamed Al Omari, Walid A. Mourad, Yasser Khafaga, Sheikha Al Thani, Mohamed Al Shabana, Adnan Ezzat, Mohamed Shoukri, Abdelghani Tbakhi |
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Rok vydání: | 2008 |
Předmět: |
Adult
Pathology medicine.medical_specialty Adolescent CD30 Lymphocyte lcsh:RC254-282 Immunophenotyping Diagnosis Differential Young Adult Antigens CD Antigens Neoplasm hemic and lymphatic diseases Biomarkers Tumor Humans Medicine Child B-cell lymphoma Histiocyte Aged Aged 80 and over CD20 biology lcsh:RC633-647.5 business.industry Histology lcsh:Diseases of the blood and blood-forming organs General Medicine Hematology Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Hodgkin Disease Immunohistochemistry Lymphoma medicine.anatomical_structure Oncology Child Preschool biology.protein Lymphoma Large B-Cell Diffuse business |
Zdroj: | Hematology/Oncology and Stem Cell Therapy, Vol 1, Iss 1, Pp 22-27 (2008) |
ISSN: | 1658-3876 |
DOI: | 10.1016/s1658-3876(08)50056-2 |
Popis: | BACKGROUND Features of T-cell/histiocyte rich large B-cell lymphoma (THRLBCL) overlap with those of lymphocyte predominant Hodgkin lymphoma (LPHL). The two lymphomas may represent a spectrum of the same disease, and differentiation between the two can sometimes be difficult. We looked at histomorphologic, immunophenotypic and clinical information that may help differentiate the two entities. METHODS Cases of THRLBCL and LPHL were blindly reviewed and studied for histological pattern (nodular vs. diffuse), nuclear features and pattern of expression of CD20, CD30, CD57, epithelial membrane antigen (EMA) and Epstein-Barr virus (EBV). A score encompassing diffuse histology, high nuclear grade, CD20 single-cell pattern, CD30 +, CD57-, EMA-, and EBV + was estimated for the diagnosis of TCHRLBCL. RESULTS There were 58 cases, including 30 cases of TCHRLBL and 28 cases of LPHL. The median age was 36 years for TCHRLBCL and 21 years for LPHL (P = 0.0001). Three types of nuclei were identified (lymphocytic/histocytic, Reed-Sternberg and centroblast-like). The latter two high-grade nuclei were suggestive of TCHRLBCL. TCHRLBCL and LPHL, respectively, showed diffuse histology, 90% vs. 4% (P = 0.001), single CD20 + cells, 93% vs. 3.5% (P = 0.00004), CD30 + cells, 30% vs. 0% (P = 0.01), CD57 + cells, 41% vs. 93% (P = 0.008), EMA + cells, 27% vs. 60% (P = 0.113), EBV + cells, 24% vs. 0% (P = 0.117), high nuclear grade, 70% vs. 0% (P = 0.001), total score 2-7 (mean 4.68) vs. 0-2 (mean 0.72) (P = 0.001), high stage, 86% vs. 7% (P = 0.0001). CONCLUSION Our findings indicate that a combination of multiple parameters can help differentiate between the two diseases. Two cases originally diagnosed as LPHL were re-assigned the diagnosis of THRLBCL. |
Databáze: | OpenAIRE |
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