Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior maxilla (Type IV bone) in non-human primates
| Autor: | Michael D. Rohrer, Hari S. Prasad, Ulf M.E. Wikesjö, John M. Wozney, Rachel G. Sorensen, Jan Hall, Andreas V. Xiropaidis, Yi Hao Huang |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Bone density Surface Properties Bone Morphogenetic Protein 2 Dentistry chemistry.chemical_element Bone morphogenetic protein Bone morphogenetic protein 2 Bone and Bones Osseointegration Dental Materials Coated Materials Biocompatible Implants Experimental Tissue engineering Bone Density Transforming Growth Factor beta Maxilla Animals Humans Dental Implants Titanium Dose-Response Relationship Drug business.industry Chemistry Dental Implantation Endosseous Recombinant Proteins Dose–response relationship Microscopy Fluorescence Bone Morphogenetic Proteins Macaca Periodontics Implant business |
| Zdroj: | Journal of Clinical Periodontology. 35:992-1000 |
| ISSN: | 1600-051X 0303-6979 |
| DOI: | 10.1111/j.1600-051x.2008.01322.x |
| Popis: | BACKGROUND Studies using ectopic rodent and orthotopic canine models (Type II bone) have shown that titanium porous oxide (TPO) surface implants adsorbed with recombinant human bone morphogenetic protein-2 (rhBMP-2) induce local bone formation including osseointegration. The objective of this study was to evaluate local bone formation and osseointegration at such implants placed into Type IV bone. MATERIAL AND METHODS rhBMP-2-coated implants were installed into the edentulated posterior maxilla in eight young adult Cynomolgus monkeys: four animals each received three TPO implants adsorbed with rhBMP-2 (2.0 mg/ml) and four animals each received three TPO implants adsorbed with rhBMP-2 (0.2 mg/ml). Contra-lateral jaw quadrants received three TPO implants without rhBMP-2 (control). Treatments were alternated between left and right jaw quadrants. Mucosal flaps were advanced and sutured to submerge the implants. The animals received fluorescent bone markers at weeks 2, 3, 4, and at week 16 when they were euthanized for histologic analysis. RESULTS Clinical healing was uneventful. Extensive local bone formation was observed in animals receiving implants adsorbed with rhBMP-2 (2.0 mg/ml). The newly formed bone exhibited a specific pinpoint bone-implant contact pattern regardless of rhBMP-2 concentration resulting in significant osseointegration; rhBMP-2 (2.0 mg/ml): 43% and rhBMP-2 (0.2 mg/ml): 37%. Control implants exhibited a thin layer of bone covering a relatively larger portion of the implant threads. Thus, TPO control implants bone exhibited significantly greater bone-implant contact ( approximately 75%; p |
| Databáze: | OpenAIRE |
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