EFFICACY OF ORALLY ADMINISTERED ONDANSETRON IN THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING: A DOSE RANGING STUDY
| Autor: | J. Leeser, M. Rust, Gnc Kenny, P. Saur, David J. Rowbotham, M. Onsrud, H. Lip, J.D.L. Oates, C.G. Haigh |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Adolescent medicine.drug_class Nausea medicine.medical_treatment Administration Oral Placebo Drug Administration Schedule Ondansetron Postoperative Complications Double-Blind Method Anesthesia Obstetrical Humans Medicine Antiemetic Aged Chemotherapy business.industry Imidazoles Middle Aged Dose-ranging study Anesthesiology and Pain Medicine Anesthesia Vomiting Antiemetics Female medicine.symptom business Postoperative nausea and vomiting medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 68:466-470 |
| ISSN: | 0007-0912 |
| Popis: | In a placebo-controlled, double-blind study, we have compared the efficacy of ondansetron 16 mg, 8 mg and 1 mg administered 8-hourly for prevention of postoperative nausea and vomiting. We studied 995 patients undergoing major gynaecological surgery; 982 were included in the analysis. Study medication was administered 1 h before induction of anaesthesia and second and third doses were given 8 and 16 h after the first. The treatment groups were similar for patient characteristics, surgical procedures, anaesthetics administered and opioids given. The frequency of nausea was 75%, 70%, 56% and 55% after placebo and ondansetron 1 mg, 8 mg and 16 mg, respectively; the corresponding frequencies of vomiting were 60%, 55%, 37% and 37%. Ondansetron 8 mg was as effective as 16 mg and both resulted in significant reductions in nausea and vomiting compared with placebo and ondansetron 1 mg (P less than 0.001). |
| Databáze: | OpenAIRE |
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