Inhibition of heat-labile toxin from Bordetella parapertussis by fatty acids
| Autor: | C R Manclark, Masaaki Nagai, Masahiko Endoh, Yasukiyo Nakase, D L Burns |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Bordetella
Linoleic acid Bacterial Toxins Guinea Pigs Immunology Prostaglandin Microbiology Bordetella parapertussis Mice chemistry.chemical_compound Species Specificity Animals Virulence Factors Bordetella Unsaturated fatty acid Skin chemistry.chemical_classification Leukotriene Transglutaminases biology Fatty Acids Fatty acid biology.organism_classification Rats Oleic acid Infectious Diseases chemistry Biochemistry lipids (amino acids peptides and proteins) Parasitology Research Article |
| Zdroj: | Infection and Immunity. 58:4045-4048 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.58.12.4045-4048.1990 |
| Popis: | The ability of heat-labile toxin (HLT) from Bordetella parapertussis to induce skin lesions in guinea pigs was found to be inhibited by lipids isolated from skin layers of adult mice, which are refractory to the lesion-inducing activity of HLT. These lipids were identified as linoleic and oleic acids. Other long-chain unsaturated fatty acids were also found to inhibit HLT; however, fatty alcohols, neutral lipids, phospholipids, cholesterol, prostaglandin, and leukotriene had no measurable effects on HLT action. The data presented in this report indicate that the ability of HLT to induce skin lesions in animals may depend, at least in part, on the free fatty acid content of the skin layer. |
| Databáze: | OpenAIRE |
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