Platelet sialic acid as a potential pathogenic factor in coronary heart disease
| Autor: | Jürgen Krappe, Wolfgang Wesemann, Claus Opper, Robert Mandic |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Platelet Aggregation Surface Properties Thiobarbituric acid Neuraminidase Coronary Disease Thiobarbituric Acid Reactive Substances Pathogenesis chemistry.chemical_compound Bacterial Proteins Internal medicine Centrifugation Density Gradient medicine Humans Platelet Myocardial infarction Thrombus chemistry.chemical_classification biology Platelet Count Hematology medicine.disease N-Acetylneuraminic Acid Sialic acid Endocrinology chemistry Immunology biology.protein Glycoprotein |
| Zdroj: | Thrombosis Research. 106:137-141 |
| ISSN: | 0049-3848 |
| Popis: | It was previously reported that, compared to healthy individuals, patients with coronary heart disease (CHD) exhibit a higher proportion of platelets with lower densities and higher propensity to aggregate. Reasons for this increased tendency to aggregate were unknown but appeared to be independent of the patient's age, gender, or smoking habits. Sialic acid (N-acetyl-neuraminic acid), a negatively charged sugar and constituent of many glycoproteins and gangliosides, is known to confer the bulk of negative charges to mammalian cell surfaces. These negatively charged surfaces can help cells of the bloodstream to maintain a relative distance from each other due to repulsion of the same (negative) charges. In this study, we examined whether differences in platelet sialic acid are a potential pathogenic factor in patients with coronary heart disease. Upon isolating platelets, we found a significantly higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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