Genetic-based differences in neurotensin levels and receptors in brains of LS × SS mice
| Autor: | Richard A. Radcliffe, V.G. Erwin, Jones Bc, Hinkle B |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Genotype Physiology Ratón Hypothalamus Radioimmunoassay Mice Inbred Strains Endogeny Nucleus accumbens Biology Biochemistry Nucleus Accumbens Midbrain Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Mesencephalon Internal medicine medicine Animals Receptors Neurotensin Receptor Neurotensin Putamen Brain Levocabastine chemistry Caudate Nucleus medicine.drug |
| Zdroj: | Peptides. 14:821-828 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/0196-9781(93)90120-6 |
| Popis: | Levels of endogenous neurotensin (NT-IR) in the LS × SS RI strains differed by 3.0-, 4.7-, 5.4-, and 6.9-fold in the ventral midbrain (VMB), hypothalamus (HY), nucleus accumbens (NA), and caudate putamen (CP), respectively. Frequency distributions and estimates of the number of genes indicate that differences in NT-IR are polygenically influenced. The NT-IR levels in NA and CP were significantly correlated, but levels in the VMB did not correlate with those in the NA or CP. Specific binding to either low (NT L )- or high (NT H )-affinity receptors as measured in the absence or presence of levocabastine differed significantly in brain regions from among LS × SS mouse strains. Results indicate a polygenic influence mediating the differences in receptor densities and suggest differences in genetic regulation of NT L and NT H receptors. |
| Databáze: | OpenAIRE |
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