Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice
| Autor: | Thomas C. Foster, Asha Rani, Ashok V. Kumar, Li Cui, Susan L. Semple-Rowland |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Genetic Vectors Green Fluorescent Proteins Estrogen receptor Hippocampus Gene mutation Biology Hippocampal formation Response Elements Benzoates Synaptic Transmission Article Immunoenzyme Techniques Mice Internal medicine Drug Discovery Chlorocebus aethiops Rhabdomyosarcoma Genetics medicine Animals Estrogen receptor activity Maze Learning Molecular Biology Estrogen receptor beta Cells Cultured Pharmacology Mice Knockout Estradiol Estrogen Receptor alpha Gene Transfer Techniques Brain Electrophysiology Mice Inbred C57BL Endocrinology Estrogen Space Perception COS Cells Molecular Medicine Female Estrogen receptor alpha |
| Zdroj: | Molecular therapy : the journal of the American Society of Gene Therapy. 16(9) |
| ISSN: | 1525-0024 |
| Popis: | Estrogen, which influences both classical genomic and rapid membrane-associated signaling cascades, has been implicated in the regulation of hippocampal function, including spatial learning. Gene mutation studies suggest that estrogen effects are mediated by estrogen receptor-alpha (ER-alpha); however, because gonadal steroids influence the organization of the hippocampus during development, it has been difficult to distinguish developmental effects from those specific to adults. In this study we show that lentiviral delivery of the gene encoding ER-alpha to the hippocampus of adult ER-alpha-knockout (ER-alphaKO) mice restores hippocampal responsiveness to estrogen and rescues spatial learning. We propose that constitutive estrogen receptor activity is important for maintaining hippocampus-dependent memory function in adults. |
| Databáze: | OpenAIRE |
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