Anticoagulant-related nephropathy: a case report and review of the literature of an increasingly recognized entity
| Autor: | Anila Duni, Georgios Liapis, Paulos Karolos Rapsomanikis, Sofia Xiromeriti, Rigas Kalaitzidis, Moses Elisaf, Olga Balafa |
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| Rok vydání: | 2016 |
| Předmět: |
Nephrology
medicine.medical_specialty Pathology medicine.drug_class Urology 030232 urology & nephrology 030204 cardiovascular system & hematology Gastroenterology Nephropathy Dabigatran 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Medicine Humans Renal Insufficiency Chronic Aged Hematuria business.industry Anticoagulant Warfarin Anticoagulants Atrial fibrillation Glomerulonephritis Glomerulonephritis IGA Acute Kidney Injury medicine.disease Female business Kidney disease medicine.drug |
| Zdroj: | International urology and nephrology. 49(8) |
| ISSN: | 1573-2584 |
| Popis: | Treatment with oral anticoagulants has been associated with worsening kidney function in patients with chronic kidney disease (CKD) as well as among patients without underlying CKD. Thus, anticoagulant-related nephropathy (ARN) is an increasingly recognized entity nowadays, mainly associated with warfarin anticoagulation. Recent evidence indicates that patients treated with the direct anticoagulants may also be at risk of ARN. However, the true incidence of anticoagulant-related nephropathy is difficult to determine. The typical histological lesion involves renal tubular occlusion by red blood cells (RBCs), tubular red blood cell casts on light microscopy and dysmorphic RBCs in the glomerulus on electron microscopy. In the absence of active glomerulonephritis or other inflammatory changes that could account for glomerular hemorrhage, the above findings confirm the diagnosis. Dabigatran etexilate was the first direct oral anticoagulant approved for stroke prevention in patients with non-valvular atrial fibrillation. In this article, we describe a rare case of dabigatran etexilate-induced nephropathy in a patient with preexisting IgA nephropathy and review the recent literature regarding this increasingly recognized entity. |
| Databáze: | OpenAIRE |
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