Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of its Background
| Autor: | M. V. Pokrovski, Dubrovin Gm, Ivanov Av, Gudyrev Os, A V Faitel'son, D. S. R. Rajkumar |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Article Subject Endocrinology Diabetes and Metabolism medicine.medical_treatment Osteoporosis Urology lcsh:Medicine Microcirculation Comparative evaluation Endocrinology Internal medicine medicine Enalapril Endothelial dysfunction Reduction (orthopedic surgery) business.industry lcsh:R medicine.disease Losartan Bone Trabeculae Angiotensin Receptor Blockers business hormones hormone substitutes and hormone antagonists Research Article circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Osteoporosis, Vol 2013 (2013) Journal of Osteoporosis |
| ISSN: | 2161-0533 |
| DOI: | 10.4172/2161-0533.1000111 |
| Popis: | In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed that in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabeculae and in preventing the occurrence of these microfractures, as well as increasing quality of experimental fractures healing. |
| Databáze: | OpenAIRE |
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