Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India
| Autor: | Adnan Raina, Ab. Hameed Raina, Qayum Hamid Changal, Manzoor Raina, Rehana Bashir, Khalid Hamid Changal, Tanveer Mir, Muzamil Latief |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male 0301 basic medicine Serotype medicine.medical_specialty Secondary dengue 030106 microbiology 030231 tropical medicine India Enzyme-Linked Immunosorbent Assay Dengue virus Antibodies Viral Serogroup medicine.disease_cause Sensitivity and Specificity Immunoglobulin G Serology Dengue fever Dengue Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Medical microbiology Reference Values medicine Humans biology Platelet Count business.industry Dengue Virus Middle Aged medicine.disease PCR Infectious Diseases Immunoglobulin M Immunology biology.protein ELISA Female Differential diagnosis business Research Article |
| Zdroj: | BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-016-2053-6 |
| Popis: | Background Secondary dengue causes more severe disease than the primary. Early on, it is important to differentiate the two. We tried to find important clinical and laboratory differences between the two for the purpose of early differentiation. Methods One hundred fourteen patients confirmed on reverse transcriptase-polymerase chain reaction (RT PCR) were studied. On day 2 of illness IgM and IgG indices were studied for calculation of IgG/IgM ratio. A one-step immunochromatographic assay was used for classification of patients into primary and secondary dengue. Patient characteristics were also studied. Results Dengue serotype 1 was the most common found in 60.5% patients. 66.7% (76 patients) had secondary dengue. Secondary dengue cases had a higher mean temperature (101.56 ± 1.55 vs. 100.79 ± 1.25,°F, p 0.015), lower platelet counts (50.51 ± 38.91 vs. 100.45 ± 38.66, x 103/micl, p |
| Databáze: | OpenAIRE |
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