Focal Areas of High Signal Intensity in Children with Neurofibromatosis Type 1: Expected Evolution on MRI
| Autor: | Thomas Blauwblomme, Christelle Dufour, F. Bourdeaut, D. Grevent, M.P. Robert, R. Calvez, Volodia Dangouloff-Ros, François Doz, Raphael Levy, Nathalie Boddaert, Charles-Joris Roux, Jacques Grill, S. Calvez, Yvonne Purcell, K. Beccaria |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Neurofibromatosis 1 Adolescent Population Posterior fossa Pediatrics 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine Image Interpretation Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging Longitudinal Studies Neurofibromatosis Child education Retrospective Studies education.field_of_study High signal intensity business.industry Brain Infant medicine.disease Magnetic Resonance Imaging Mr imaging Hyperintensity medicine.anatomical_structure Child Preschool Female Neurology (clinical) Radiology Mr images business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a6740 |
| Popis: | BACKGROUND AND PURPOSE: Focal areas of high signal intensity are T2WI/T2-FLAIR hyperintensities frequently found on MR imaging of children diagnosed with neurofibromatosis type 1, often thought to regress spontaneously during adolescence or puberty. Due to the risk of tumor in this population, some focal areas of high signal intensity may pose diagnostic problems. The objective of this study was to assess the characteristics and temporal evolution of focal areas of high signal intensity in children with neurofibromatosis type 1 using long-term follow-up with MR imaging. MATERIALS AND METHODS: We retrospectively examined the MRIs of children diagnosed with neurofibromatosis type 1 using the National Institutes of Health Consensus Criteria (1987), with imaging follow-up of at least 4 years. We recorded the number, size, and surface area of focal areas of high signal intensity according to their anatomic distribution on T2WI/T2-FLAIR sequences. A generalized mixed model was used to analyze the evolution of focal areas of high signal intensity according to age, and separate analyses were performed for girls and boys. RESULTS: Thirty-nine patients (ie, 285 MR images) with a median follow-up of 7 years were analyzed. Focal areas of high signal intensity were found in 100% of patients, preferentially in the infratentorial white matter (35% cerebellum, 30% brain stem) and in the capsular lenticular region (22%). They measured 15 mm in 95% of cases. They appeared from the age of 1 year; increased in number, size, and surface area to a peak at the age of 7; and then spontaneously regressed by 17 years of age, similarly in girls and boys. CONCLUSIONS: Focal areas of high signal intensity are mostly small ( |
| Databáze: | OpenAIRE |
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