Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes
| Autor: | Mohamed Lamine Mariko, Hervé Le Stunff, Yacir Benomar, Cécile L. Bandet, Jeanne Guitton, Sophie Tan-Chen, Eric Hajduch, Olivier Bourron |
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| Přispěvatelé: | Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Service de Diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de diabétologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Ceramide obesity Sphingosine-1-phosphate medicine.medical_treatment Review [SDV.BC]Life Sciences [q-bio]/Cellular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Sphingosine Internal medicine insulin resistance medicine Glucose homeostasis Animals Humans Insulin hypothalamus lcsh:QH301-705.5 ComputingMilieux_MISCELLANEOUS 030304 developmental biology Mammals 0303 health sciences biology Chemistry General Medicine Metabolism medicine.disease Insulin receptor Endocrinology Lipotoxicity Diabetes Mellitus Type 2 lcsh:Biology (General) biology.protein lipids (amino acids peptides and proteins) type 2 diabetes Lysophospholipids Energy Metabolism pancreatic β cell fate 030217 neurology & neurosurgery |
| Zdroj: | Cells Cells, MDPI, 2020, 9 (7), pp.1682. ⟨10.3390/cells9071682⟩ Cells, Vol 9, Iss 1682, p 1682 (2020) |
| ISSN: | 2073-4409 |
| Popis: | Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads to the dysregulation of glucose homeostasis, which culminates in the onset of type 2 diabetes (T2D). FFA, which accumulate in these tissues, are metabolized as lipid derivatives such as ceramide, and the ectopic accumulation of the latter has been shown to lead to lipotoxicity. Ceramide is an active lipid that inhibits the insulin signaling pathway as well as inducing pancreatic β cell death. In mammals, ceramide is a key lipid intermediate for sphingolipid metabolism as is sphingosine-1-phosphate (S1P). S1P levels have also been associated with the development of obesity and T2D. In this review, the current knowledge on S1P metabolism in regulating insulin signaling in pancreatic β cell fate and in the regulation of feeding by the hypothalamus in the context of obesity and T2D is summarized. It demonstrates that S1P can display opposite effects on insulin sensitive tissues and pancreatic β cells, which depends on its origin or its degradation pathway. |
| Databáze: | OpenAIRE |
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