A Meta-analysis of the Rates of Listeria monocytogenes and Enterococcus in Febrile Infants
| Autor: | Rianna Leazer, Kyrie Shomaker, Amy M. Perkins, Bryan R. Fine |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Fever medicine.drug_class Antibiotics Bacteremia Context (language use) medicine.disease_cause Pediatrics Microbiology 03 medical and health sciences 0302 clinical medicine Listeria monocytogenes Streptococcal Infections 030225 pediatrics Internal medicine Epidemiology Prevalence Humans Medicine Listeriosis Meningitis 030212 general & internal medicine biology business.industry Infant General Medicine biology.organism_classification medicine.disease United States Anti-Bacterial Agents Enterococcus Meta-analysis Urinary Tract Infections Pediatrics Perinatology and Child Health business |
| Zdroj: | Hospital Pediatrics. 6:187-195 |
| ISSN: | 2154-1671 2154-1663 |
| DOI: | 10.1542/hpeds.2015-0187 |
| Popis: | CONTEXT: A change in the epidemiology of pathogens causing serious bacterial infection (SBI) has been noted since original recommendations were made for the empirical antibiotic choices for young infants with fever. OBJECTIVE: To assess the prevalence of SBI caused by Listeria monocytogenes and Enterococcus species. DATA SOURCES: A literature search was conducted on keywords related to SBI, L. monocytogenes, and Enterococcus spp. infections. STUDY SELECTION: Eligible studies were those conducted in the United States and published between January 1998 and June 2014 focusing on SBI in infants ≤90 days of age. DATA EXTRACTION: The rates of urinary tract infection, bacteremia, and meningitis for each pathogen were recorded for each study. Meta-analysis was performed to calculate the prevalence for each pathogen in a random effects model with 0.5 continuity correction added to studies with zero events. RESULTS: Sixteen studies were included. A total of 20 703 blood cultures were included, with weighted prevalences for L. monocytogenes and Enterococcus spp. bacteremia of 0.03% and 0.09%, respectively. A total of 13 775 cerebrospinal fluid cultures were included with event rates (unweighted prevalences) for L. monocytogenes and Enterococcus spp. meningitis of 0.02% and 0.03%, respectively. A total of 18 283 urine cultures were included, with no cases of L. monocytogenes and a weighted prevalence for Enterococcus spp. urinary tract infection of 0.28%. LIMITATIONS: There may have been reporting bias or incomplete retrieval or inadvertent exclusion of relevant studies. CONCLUSIONS: SBI caused by L. monocytogenes and Enterococcus spp. in febrile infants is rare, and therefore clinicians may consider a change in empirical antibiotic choices. |
| Databáze: | OpenAIRE |
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