Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula
| Autor: | František Kolář, Jiří Novotný, Lucie Hejnova, Petr Kujal, Zdeňka Vaňourková, Janusz Sadowski, Elzbieta Kompanowska-Jezierska, Soňa Kikerlová, Šárka Jíchová, Zuzana Husková, Olga Gawrys, Luděk Červenka, Zuzana Honetschlägerová, Vojtěch Melenovský, Petra Škaroupková |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system hypertension 030232 urology & nephrology Urology angiotensin ii Kidney lcsh:RC870-923 digestive system Norepinephrine (medication) Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine medicine.artery Renin medicine lcsh:Dermatology Animals Renal artery Sympathectomy renal denervation Denervation Heart Failure business.industry fungi renal blood flow General Medicine Blood flow renal vascular reactivity lcsh:RL1-803 medicine.disease lcsh:Diseases of the genitourinary system. Urology Angiotensin II digestive system diseases Rats congestive heart failure Nephrology Renal sympathetic denervation lcsh:RC666-701 Heart failure Renal blood flow Arteriovenous Fistula aortocaval fistula Female Rats Transgenic Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Kidney & Blood Pressure Research, Vol 46, Iss 1, Pp 95-113 (2021) |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Objective: We examined if renal denervation (RDN) attenuates the progression of aortocaval fistula (ACF)-induced heart failure or improves renal hemodynamics in Ren-2 transgenic rats (TGR), a model of angiotensin II (ANG II)-dependent hypertension. Methods: Bilateral RDN was performed 1 week after creation of ACF. The animals studied were ACF TGR and sham-operated controls, and both groups were subjected to RDN or sham denervation. In separate groups, renal artery blood flow (RBF) responses were determined to intrarenal ANG II (2 and 8 ng), norepinephrine (NE) (20 and 40 ng) and acetylcholine (Ach) (10 and 40 ng) 3 weeks after ACF creation. Results: In nondenervated ACF TGR, the final survival rate was 10 versus 50% in RDN rats. RBF was significantly lower in ACF TGR than in sham-operated TGR (6.2 ± 0.3 vs. 9.7 ± 0.5 mL min−1 g−1, p < 0.05), the levels unaffected by RDN. Both doses of ANG II decreased RBF more in ACF TGR than in sham-operated TGR (−19 ± 3 vs. −9 ± 2% and −47 ± 3 vs. −22 ± 2%, p < 0.05 in both cases). RDN did not alter RBF responses to the lower dose, but increased it to the higher dose of ANG II in sham-operated as well as in ACF TGR. NE comparably decreased RBF in ACF TGR and sham-operated TGR, and RDN increased RBF responsiveness. Intrarenal Ach increased RBF significantly more in ACF TGR than in sham-operated TGR (29 ± 3 vs. 17 ± 3%, p < 0.05), the changes unaffected by RDN. ACF creation induced marked bilateral cardiac hypertrophy and lung congestion, both attenuated by RDN. In sham-operated but not in ACF TGR, RDN significantly decreased mean arterial pressure. Conclusion: The results show that RDN significantly improved survival rate in ACF TGR; however, this beneficial effect was not associated with improvement of reduced RBF or with attenuation of exaggerated renal vascular responsiveness to ANG II. |
| Databáze: | OpenAIRE |
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