Influence of chitosan average molecular weight on degradation and stability of electrodeposited conduits
Autor: | Radoslaw A. Wach, Marek Wieczorek, Michał Tylman, Katarzyna Nawrotek, Karolina Rudnicka, Justyna Gatkowska, Agnieszka Adamus-Włodarczyk |
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Rok vydání: | 2019 |
Předmět: |
chemistry.chemical_classification
Polymers and Plastics Organic Chemistry 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology Phosphate 01 natural sciences 0104 chemical sciences law.invention Chitosan chemistry.chemical_compound chemistry Magazine law Self-healing hydrogels Materials Chemistry Molar mass distribution Degradation (geology) Lysozyme 0210 nano-technology Biomedical engineering |
Zdroj: | Carbohydrate polymers. 244 |
ISSN: | 1879-1344 |
Popis: | Tubular chitosan-based hydrogels, obtained in an electrodeposition process, are subject of degradation and stability studies. The implants are prepared from polymer with different average molecular weight. This approach allows fabricating structures that vary in mass and wall thickness. The obtained implants are incubated in phosphate buffered solution (pH 7.4) with or without lysozyme up to 56 days at 37 °C. Subsequently, chemical, physical as well as mechanical properties of implants are evaluated. Although the initial physicomechanical properties are different, they change upon incubation and remain similar over its period. Finally, in vitro biocompatibility of implants is proven after assessing their action towards mHippoE-18 embryonic hippocampal cells and THP1-XBlue™ monocytes. Since dimensions of nerves and the gap length differ across the body and injury, respectively, the possibility to control properties of chitosan applied gives a tool to prepare implants with wall thickness adjusted to the specific peripheral nerve injury case. |
Databáze: | OpenAIRE |
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