Early middle age cholesterol levels and the association with age-related macular degeneration
| Autor: | Ilkka Immonen, Timo E. Strandberg, Fabian Kananen, Sirpa Loukovaara |
|---|---|
| Přispěvatelé: | Faculty of Medicine, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, Geriatrian yksikkö, INDIVIDRUG - Individualized Drug Therapy, HUS Head and Neck Center, Silmäklinikka |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
cardiovascular risk factors Time Factors genetic structures Gastroenterology Macular Degeneration chemistry.chemical_compound 0302 clinical medicine Risk Factors genetics Finland Aged 80 and over 2. Zero hunger 0303 health sciences Incidence Age Factors General Medicine related macular degeneration Middle Aged 3. Good health Cholesterol Population study age‐ Adult medicine.medical_specialty Single-nucleotide polymorphism Drusen Polymorphism Single Nucleotide Risk Assessment lipids 03 medical and health sciences Age Distribution Internal medicine medicine Humans 3125 Otorhinolaryngology ophthalmology Aged Retrospective Studies 030304 developmental biology Triglyceride business.industry drusen Macular degeneration medicine.disease Middle age eye diseases Ophthalmology chemistry 030221 ophthalmology & optometry sense organs business Body mass index Biomarkers Follow-Up Studies |
| Popis: | Purpose To examine whether serum cholesterol in early middle age is associated with age-related macular degeneration (AMD) later in life. Methods A group of Helsinki Businessmen Study (HBS) participants (n = 209) were recruited for the study. Total cholesterol (TC), triglyceride and body mass index (BMI) were measured at the HBS baseline visit in 1964-1973. Lipid subfractions, BMI, smoking status and statin use were recorded in 2011 and fundus photographs graded for AMD in 2005-2012. The subjects were genotyped for the main AMD risk single nucleotide polymorphisms (SNPs). Results TC measured at baseline 1964-1973 was significantly higher in subjects later developing intermediate or late AMD (6.67 mmol/l versus 6.20 mmol/l, p = 0.024) or with drusen size of >= 125 mu m (6.68 mmol/l versus 6.21 mmol/l, p = 0.030) compared with the rest of the study population. TC, LDL and TG values at follow-up 2011 were lower in subjects with AMD compared to those without, whereas HDL levels showed no difference. In multivariate analysis, baseline TC associated with intermediate or late AMD (OR 1.59, p = 0.004) and drusen size >= 125 mu m (OR 1.57, p = 0.006) when corrected for age, BMI, AMD risk SNPs and smoking. Lipid values measured 2011 had no associations after correction. Conclusions High systemic total cholesterol in early middle age may have a role in the initial development of AMD, especially in patients later developing large drusen. |
| Databáze: | OpenAIRE |
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