| Autor: |
Tomáš Kučera, Kristína Jedličková, Marek Šramko, Petr Peichl, Jakub Cvek, Lukáš Knybel, Pavel Hurník, Radek Neuwirth, Otakar Jiravský, Luděk Voska, Josef Kautzner |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 62 |
| ISSN: |
1879-1336 |
| Popis: |
We performed a histological and immunohistochemical analysis of myocardia from 3 patients who underwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was infiltrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells including CD68+/CD11c+ macrophages, CD4+ and CD8+ T-lymphocytes and some scattered CD20+ B-lymphocytes. Mast cells were diminished in contrast to viable myocardium. In Case 2 and Case 3 (death 6 and 9 months after radiotherapy, respectively) we found mostly fibrosis, infiltration by adipose tissue and foci of calcification. Inflammatory infiltrates were less pronounced. Our observations are in accordance with animal experimental studies and confirm a progress from myolysis to fibrosis. In addition, we demonstrate a role of pro-inflammatory macrophages in the earlier stages of myocardial remodeling after stereotactic radioablation for ventricular tachycardia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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