Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital
| Autor: | Tiago Casella, Fernanda Modesto Tolentino, Milena Polotto, Ana Lúcia da Costa Darini, Maria Fernanda Campagnari Bueno, Suzana Margareth Lobo, Diego Diniz de Paula Barcelos, Natal Santos da Silva, Leonardo Neves Andrade, Mara Corrêa Lelles Nogueira, Doroti de Oliveira Garcia, Francieli Maira Moreira Batista Tomaz, Gabriela Rodrigues Franscisco |
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| Přispěvatelé: | Adolfo Lutz Inst, Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP), Uniao Fac Grandes Lagos, Hosp Base |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Microbiology (medical)
clone (Java method) medicine.drug_class Klebsiella pneumoniae medicine.medical_treatment Immunology Antibiotics Drug resistance Biology Microbiology 03 medical and health sciences Intergenic region polycyclic compounds medicine Gene 030304 developmental biology Pharmacology 0303 health sciences 030306 microbiology Critically ill multiresistance bacterial infections and mycoses biology.organism_classification KPC Beta-lactamase |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2019-10-04T12:42:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-13 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The dissemination of multiresistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing Klebsiella pneumoniae isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant K. pneumoniae isolated from 2011 to 2014 in a tertiary hospital were investigated. The bla(KPC-2) gene was the only determinant for carbapenem resistance. The bla(CTX-M-15) gene was the main determinant for the production of extended-spectrum beta-lactamase (ESBL), whereas aph(3 ')-Ia and qnrB were the most common genes associated with resistance to aminoglycosides and quinolones, respectively. Nine different sequence types (STs) were identified. The most common was ST340. Molecular typing by enterobacterial repetitive intergenic consensus-PCR placed 48 strains among 10 different clusters. In the studied hospital, the high-risk clone of KPC-2-producing K. pneumoniae ST340, harboring genes that codify aminoglycoside modifying enzymes, QnrB and CTX-M-15 plus CTXM-2-type ESBLs, is disseminated and acts as a major agent of infections in critically ill patients. Adolfo Lutz Inst, Sao Jose Do Rio Preto, Brazil Univ Estadual Paulista, Sao Jose Do Rio Preto, Brazil Fac Med Sao Jose Do Rio Preto, Dept Doencas Dermatol Infecciosas & Parasitarias, Ctr Invest Microrganismos, Sao Jose Do Rio Preto, Brazil Adolfo Lutz Inst, Ctr Bacteriol, Sao Paulo, Brazil Uniao Fac Grandes Lagos, Lab Modelagens Matemat & Estat Med, Sao Jose Do Rio Preto, SP, Brazil Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto, Brazil Hosp Base, Lab Cent, Setor Microbiol Clin, Sao Jose Do Rio Preto, Brazil Univ Estadual Paulista, Sao Jose Do Rio Preto, Brazil FAPESP: 2014/17184-00 FAPESP: 2012/21709-5 |
| Databáze: | OpenAIRE |
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