Emergence of multidrug-resistant clones of Salmonella Infantis in broiler chickens and humans in Hungary
| Autor: | Noémi Nógrády, Judit Pászti, Ágnes Kostyák, Béla Nagy, Ákos Tóth |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Salmonella Meat Nalidixic acid Microbial Sensitivity Tests Integron medicine.disease_cause Microbiology law.invention Feces Plasmid Antibiotic resistance law Drug Resistance Multiple Bacterial medicine Pulsed-field gel electrophoresis Animals Humans Pharmacology (medical) Bacteriophage Typing Polymerase chain reaction Pharmacology Genetics Hungary biology Animal Feed Electrophoresis Gel Pulsed-Field Multiple drug resistance Infectious Diseases Salmonella Infections biology.protein Chickens Plasmids medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 60:645-648 |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | Objectives: The characterization of a Salmonella Infantis strain collection that was set up from isolates of animal and human origin obtained in Hungary in recent years. Methods: All isolates were phage typed. Antimicrobial resistance was tested by the disc diffusion method, while the presence of the antimicrobial resistance genes and class 1 integrons was investigated by PCR. Genetic relatedness of the isolates was tested by PFGE and plasmid profiling. Results: The majority of the isolates representing different parts of Hungary are characterized by phage types 213 and 217 and the nalidixic acid-streptomycin-sulphonamide-tetracycline resistance type. They harbour a class 1 integron with an aadA1 gene in the 855 bp variable region, a tet(A) gene, a >168 kb plasmid and 66% of them represent one genetic clone as determined by Xbal PFGE fingerprinting. Conclusions: It seems that broiler chickens constitute a reservoir for one large and a few smaller multidrug-resistant Salmonella Infantis clones in Hungary, which might have spread to humans through chicken meat. |
| Databáze: | OpenAIRE |
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