A Single-Dose Study of the Efficacy and Safety of FS 205-397 (250 mg or 500 mg) Versus Aspirin and Placebo in the Treatment of Postsurgery Dental Pain
| Autor: | William R. Sterling, Donald R. Mehlisch, Frank A. Mazza, Jack M. Singer |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Indoles Time Factors Adolescent Nausea medicine.medical_treatment Analgesic Placebo Drug Administration Schedule Double-Blind Method medicine Humans Pharmacology (medical) Pharmacology Pain Postoperative Chemotherapy Aspirin business.industry Anti-Inflammatory Agents Non-Steroidal Anesthesia Dental surgery Toxicity Female Onset of action medicine.symptom business medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 30:815-823 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1990.tb01879.x |
| Popis: | The efficacy and safety of two dose levels of FS 205–397 (either 250 or 500 mg) were compared with the efficacy and safety of aspirin 650 mg and placebo in a 6-hour, single-dose, double-blind study in 161 patients who had undergone extraction of third molars. Each of the doses of FS 205–397, as well as aspirin, produced analgesia. However, the analgesic effects of both the 500 mg dose of FS 205–397 and aspirin were at times significantly better and more prolonged than those produced by the lower dose of FS 205–397. On the other hand, both doses of FS 205–397 had a significantly faster onset of action than aspirin. Side effects, reported by 17% of the 161 patients, did not differ significantly among the four treatment groups with respect to frequency, type, or severity. The most commonly reported side effects were nausea (7%) and drowsiness (6%). The results indicated that FS 205–397, administered in single doses of either 500 or 250 mg, is a safe and effective analgesic for the relief of pain following dental surgery, and may offer particular advantages in terms of onset of effects. |
| Databáze: | OpenAIRE |
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