Cancer Incidence after Radiotherapy for Skin Haemangioma During Infancy
| Autor: | Arne Wallgren, Per Karlsson, Lena Marie Lundberg, Erik Holmberg, Bertil Arvidsson, Sture Lindberg |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Neoplasms Radiation-Induced Skin Neoplasms Adolescent Gastroenterology Central Nervous System Neoplasms Cohort Studies Internal medicine Endocrine Gland Neoplasms Confidence Intervals medicine Humans Radiology Nuclear Medicine and imaging Registries Thyroid Neoplasms Child Thyroid cancer Sweden Radiotherapy Brain Neoplasms business.industry Incidence Incidence (epidemiology) Thyroid Infant Radiotherapy Dosage Hematology General Medicine Middle Aged medicine.disease Surgery Cancer registry Standardized mortality ratio medicine.anatomical_structure Oncology Relative risk Cohort Female Hemangioma business Follow-Up Studies Radium Cohort study |
| Zdroj: | Acta Oncologica. 34:735-740 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/02841869509127180 |
| Popis: | An infant cohort treated for skin haemangioma with 226Ra between 1930 and 1965 (n = 11,807) was studied. The median age at treatment was 5-months and 88% were treated before 12 months of age. This cohort was followed up in the Swedish Cancer Registry during the years 1958 to 1989, giving 370,517 person-years at risk. A total number of 248 malignancies have been observed and the standardized incidence ratio (SIR) was 1.21 (confidence interval (CI) 95%, 1.06-1.37). Significantly increased numbers of cancers were found in the central nervous system, 34 cases (SIR = 1.85, CI 95% 1.28-2.59), the thyroid, 15 cases (SIR = 1.88, CI 95% 1.05-3.09) and other endocrine glands, 23 cases (SIR = 2.58, CI 95% 1.64-3.87). The absorbed dose in 11 specified risk organs has been estimated using a phantom of the size of a 5-6-month-old child. The mean absorbed dose in the thyroid was 0.12 Gy and the excess relative risk (ERR) for thyroid cancer was 7.5 per Gy (CI 95% 0.4-18.1). The mean dose in the central nervous system was 0.077 Gy and the ERR for brain tumours was 10.9 per Gy (CI 95% 3.7-20.5). This cohort gives a unique opportunity to analyse long-term effects of low-dose irradiation during infancy. |
| Databáze: | OpenAIRE |
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