Nosocomial Mycobacterium tuberculosis transmission by brief casual contact identified using comparative genomics
| Autor: | Kyoko Araki, Yoshiko Otani, Katsumi Mizuta, Takayuki Wada, Tadayuki Ahiko, Tatsuya Ikeda, Junji Seto, Yu Suzuki |
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| Rok vydání: | 2018 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Tuberculosis Genotype Minisatellite Repeats Polymorphism Single Nucleotide Mycobacterium tuberculosis Patient Isolation Japan Internal medicine Epidemiology medicine Disease Transmission Infectious Humans Typing Comparative genomics Aged 80 and over biology business.industry Transmission (medicine) General Medicine Genomics Middle Aged medicine.disease biology.organism_classification Molecular Typing Variable number tandem repeat Infectious Diseases Female business |
| Zdroj: | The Journal of hospital infection. 102(1) |
| ISSN: | 1532-2939 |
| Popis: | Summary This paper reports a case of nosocomial transmission of Mycobacterium tuberculosis by brief casual contact. Routine variable number tandem repeat typing in Yamagata Prefecture, Japan found that M. tuberculosis clinical isolates from two patients showed indistinguishable genotypes. The patients had an epidemiological relationship of sharing a waiting room in a hospital on the same day. As comparative genomics detected only two single nucleotide variants between the isolates, it was concluded that recent tuberculosis transmission occurred in the waiting room. These results indicate that the physical separation of infectious tuberculosis patients is an essential control measure for preventing unpredictable nosocomial transmission by casual contact. |
| Databáze: | OpenAIRE |
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