Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer
| Autor: | Feng Li, Qingyuan Li, Yang Zhao, Chengjian Qiao, Jizhong Che |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Tumor immunity Kaplan-Meier Estimate B7-H1 Antigen Metastasis Transcriptome 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Clinical Research Antigens CD274 Biomarkers Tumor Medicine Humans Stage (cooking) Survival rate Aged Aged 80 and over Bladder cancer business.industry General Medicine Middle Aged medicine.disease Survival Analysis Immunohistochemistry Up-Regulation 030104 developmental biology Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Cancer research Female Neoplasm Recurrence Local business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL AND METHODS We investigated 110 urothelial bladder cancer cases. The expressions of B7H1 in tumors were analyzed by immunohistochemistry and RT-PCR. The correlation between B7H1 expression and survival rate was analyzed by log-rank test. RESULTS B7H1 expression was significantly increased in cancerous tissues compared to normal tissues (p0.05). B7H1 expression was not associated with sex, age, diameter, or the combination of these factors (p0.05). The positive expression of B7-H1 was positively correlated with grade, stage, recurrence, and metastasis (p0.05). The RT-PCR results were consistent with the immunohistochemistry outcomes. Furthermore, the expression of B7H1 in tumors was highly correlated with the survival rate (p0.05). CONCLUSIONS Expression of B7H1 is correlated with clinicopathologic features in bladder cancer. Up-regulation of B7H1 can result in progression and recurrence of urothelial bladder cancer. |
| Databáze: | OpenAIRE |
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