Bioinformatics Analysis of Stromal Molecular Signatures Associated with Breast and Prostate Cancer
| Autor: | Guoqing Chen, Chao Sun, Yifan Gu, Yibao Du |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Stromal cell Breast Neoplasms Biology 03 medical and health sciences Prostate cancer 0302 clinical medicine Stroma Prostate Biomarkers Tumor Genetics medicine Humans Gene Regulatory Networks Neoplasm Invasiveness Protein Interaction Maps Molecular Biology Periplakin Glutathione Transferase 030304 developmental biology 0303 health sciences Microarray analysis techniques Gene Expression Profiling Plakins Prostatic Neoplasms Cancer Genomics medicine.disease Gene Expression Regulation Neoplastic Computational Mathematics Gene Ontology medicine.anatomical_structure Computational Theory and Mathematics 030220 oncology & carcinogenesis Modeling and Simulation Dihydrotestosterone Cancer research Female Receptors Pituitary Adenylate Cyclase-Activating Polypeptide Type I medicine.drug |
| Zdroj: | Journal of Computational Biology. 26:1130-1139 |
| ISSN: | 1557-8666 |
| Popis: | This study aimed to identify stromal molecular signatures associated with breast and prostate cancer. The microarray data GSE26910 was downloaded from Gene Expression Omnibus database, including six invasive breast tumor stroma, six matched normal controls, six invasive prostate tumor stroma, and six matched controls. The differentially expressed genes (DEGs) in invasive breast and prostate tumors stroma were, respectively, identified. Then common stromal genes (B_P.DEGs) were further screened. Protein-protein interaction (PPI) network was constructed and Gene Ontology analysis was performed. Besides, gene-chemical interactions were mapped in Comparative Toxicogenomics Database to screen the chemicals related to feature genes. The results showed that, in total, 16 B_P.DEGs were identified. Thereinto, only seven B_P.DEGs were mapped into PPI, and only four functional modules (adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) module, aspartoacylase (ASPA) module, glutathione S-transferase mu 5 (GSTM5) module, and periplakin (PPL) module) were involved in important biological processes associated with cancer progression. In addition, the chemicals, such as dihydrotestosterone, apocarotenal, testosterone, and progesterone, were screened for the roles of feature genes in the progression of breast and prostate cancer. In conclusion, ADCYAP1R1, GSTM5, and PPL were stromal molecular signatures and might play a key role in the progression of breast and prostate cancer. |
| Databáze: | OpenAIRE |
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