Patients with posttraumatic stress disorder exhibit an altered phenotype of regulatory T cells
| Autor: | Mladen Jergović, Ante Sabioncello, Valerija Vojvoda, Sabina Rabatić, Krešo Bendelja, Tanja Jovanovic, Ana Savić, Anđelko Vidović, Neda Aberle |
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| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Allergy Population chemical and pharmacologic phenomena Autoimmunity medicine.disease_cause Peripheral blood mononuclear cell In vivo Immunology and Allergy Medicine Interleukin-7 receptor education education.field_of_study business.industry Research Posttraumatic stress disorder hemic and immune systems General Medicine Regulatory T cells medicine.disease Phenotype 3. Good health Posttraumatic stress Immunology business |
| Zdroj: | Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology |
| ISSN: | 1710-1484 |
| Popis: | Background Regulatory T cells (Tregs) play a key role in immune homeostasis in vivo. Tregs have a critical role in preventing the development of autoimmune diseases and defects in Treg function are implicated in various autoimmune disorders. Individuals with posttraumatic stress disorder (PTSD) have higher prevalence of autoimmune disorders than the general population. We hypothesized that war veterans with PTSD would exhibit a decreased number and/or altered phenotype of Tregs. Methods We analyzed peripheral blood mononuclear cells (PBMCs) of patients with PTSD (N = 21) (mean age = 45.9) and age-matched healthy controls (N = 23) (mean age = 45.7) to determine the proportion of Tregs and their phenotype according to the expression of CD127 and HLA-DR markers which describe the differentiation stages of Tregs. In addition, we analyzed the expression of membrane ectoenzyme CD39 on Tregs of the study groups, an important component of the suppressive machinery of Tregs. Results We found no differences in the proportion of Tregs between PTSD patients and controls, but PTSD patients had a higher percentage of CD127-HLA-DR- Tregs and a lower percentage of CD127loHLA-DR+ Tregs compared to controls. There was no difference in expression of CD39 on Tregs of the study groups. Conclusions Although the proportions of Tregs in PTSD patients were unchanged, we found that they exhibit a different phenotype of Tregs that might be less suppressive. Impaired differentiation and function of Tregs is likely involved in disruption of immune homeostasis in PTSD. |
| Databáze: | OpenAIRE |
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