Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese
| Autor: | Yi-Ying Lin, Cheng-Wen Su, Lung-An Hsu, Leay-Kiaw Er, Semon Wu, Ching-Hua Yeh, Ming-Sheng Teng, Wan-Yi Hsiao, Jeng-Feng Lin, Yu-Lin Ko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Candidate gene Heredity lcsh:Medicine Gene Expression Genome-wide association study Pathology and Laboratory Medicine TNFAIP3 Biochemistry Vascular Medicine Database and Informatics Methods Medicine and Health Sciences IKBKE lcsh:Science Immune Response Genetics education.field_of_study Multidisciplinary NF-kappa B Nuclear Proteins Genomics Proteases Middle Aged Genomic Databases Intercellular Adhesion Molecule-1 Enzymes Genetic Mapping Cardiovascular Diseases Female Co-Repressor Proteins Research Article Adult Genotyping Population Immunology Taiwan Single-nucleotide polymorphism Variant Genotypes Biology Research and Analysis Methods Polymorphism Single Nucleotide 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Genome-Wide Association Studies Diabetes Mellitus Humans Gene Regulation Allele education Molecular Biology Techniques Molecular Biology Genetic association Inflammation lcsh:R Biology and Life Sciences Computational Biology Proteins Human Genetics Genome Analysis Atherosclerosis 030104 developmental biology Biological Databases Enzymology Metalloproteases lcsh:Q Biomarkers |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 1, p e0169516 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Intercellular adhesion molecule-1 (ICAM1) is crucial to the development and progression of atherosclerosis. Recent genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) in two of the nuclear factor-κB (NF-κB) pathway genes, NFKBIK and RELA, are associated with soluble ICAM1 (sICAM1) levels. However, neither of these two gene variants is found in the Asian populations. This study aimed to elucidate whether other candidate gene variants involved in the NF-κB pathway may be associated with sICAM1 levels in Taiwanese. After excluding carriers of the ICAM1 rs5491-T allele, three SNPs in the ICAM1 gene and eight SNPs in six of the NF-κB pathway genes (NFKB1, PDCD11, TNFAIP3, NKAPL, IKBKE, and PRKCB) were analyzed for their association with sICAM1 levels in 480 individuals. Our data showed that two SNPs, rs5498 of ICAM1 and rs1635 of NKAPL, were significantly associated with sICAM1 levels (P = 0.002 and 0.004, respectively) in the Taiwanese population. Using a multivariate analysis, rs5498 and rs1635 as well as the previously reported ABO genotypes and rs12051272 of the CDH13 gene were independently associated with sICAM1 levels (P = 0.001, 0.001, 0.006 and 0.031, respectively). An analysis with combined risk alleles of four candidate SNPs in the ICAM1, NKAPL, ABO, and CDH13 genes showed an increase in sICAM1 levels with added numbers of risk alleles and weighted genetic risk score. Our findings thus expanded the repertoire of gene variants responsible for the regulation of sICAM1 levels in the Asian populations. |
| Databáze: | OpenAIRE |
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