Tolerability of ibuprofen and flurbiprofen in G-6-PD deficient subjects: in vitro study
| Autor: | PK Pispati, AJ Baxi, Sheth Uk, SP Valame, K. Gupta, V N Kulkarni |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Primaquine Erythrocytes Flurbiprofen Ibuprofen Pharmacology Glycogen Storage Disease Type I chemistry.chemical_compound medicine Humans Pharmacology (medical) Incubation Glycogen storage disease type I Aspirin Chemistry Glutathione medicine.disease Tolerability Female Propionates medicine.drug Research Article |
| Zdroj: | British journal of clinical pharmacology. 11(3) |
| ISSN: | 0306-5251 |
| Popis: | 1 A 'GSH (reduced glutathione) stability test' which consists of incubating blood samples with acetylphenylhydrazine and other test drugs and measuring GSH level before and after incubation, was carried out. 2 Application of this test to the blood of eight normal volunteers and twelve known G-6-PD deficient persons demonstrated that acetylphenylhydrazine and primaquine produced a significant decrease in GSH levels in G-6-PD deficient red cells compared to the reduction seen in normal red cells incubated with these drugs. No such change was observed with aspirin, ibuprofen and flurbiprofen. 3 The results of this in vitro study seem to indicate that ibuprofen and flurbiprofen are relatively innocuous in G-6-PD deficient individuals. |
| Databáze: | OpenAIRE |
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