Endoreplication: A Molecular Trick during Animal Neuron Evolution
| Autor: | Mauro Mandrioli, Barbara Cuoghi, Dario Sonetti, Lucrezia Mola |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Nervous system
neuron evolution Haploidy Biology Genome DNA endoreplication mollusc fish nervous system biology.animal medicine Animals Endoreduplication Arthropods Mollusca Mammals Neurons Ecology Vertebrate biology.organism_classification Biological Evolution Order (biology) medicine.anatomical_structure Evolutionary biology Magnocellular cell Neuron General Agricultural and Biological Sciences Cell Division |
| Zdroj: | The Quarterly Review of Biology. 85:159-169 |
| ISSN: | 1539-7718 0033-5770 |
| DOI: | 10.1086/652341 |
| Popis: | The occurrence of endoreplication has been repeatedly reported in many organisms, including protists, plants, worms, arthropods, molluscs, fishes, and mammals. As a general rule, cells possessing endoreplicated genomes are large-sized and highly metabolically active. Endoreplication has not been frequently reported in neuronal cells that are typically considered to be fully differentiated and non-dividing, and which normally contain a diploid genome. Despite this general statement, various papers indicate that giant neurons in molluscs, as well as supramedullary and hypothalamic magnocellular neurons in fishes, contain DNA amounts larger than 2C. In order to study this issue in greater detail here, we review the available data about endoreplication in invertebrate and vertebrate neurons, and discuss its possible functional significance. As a whole, endoreplication seems to be a sort of molecular trick used by neurons in response to the high functional demands that they experience during evolution. |
| Databáze: | OpenAIRE |
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