Prenatal naled and chlorpyrifos exposure is associated with deficits in infant motor function in a cohort of Chinese infants
| Autor: | Minjian Chen, Yankai Xia, John D. Meeker, Binquan Zhu, Betsy Lozoff, Jie Shao, Niko Kaciroti, Monica K. Silver |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine China Insecticides Developmental Disabilities Population Naled Physiology 010501 environmental sciences 01 natural sciences Cohort Studies Toxicology 03 medical and health sciences chemistry.chemical_compound Pregnancy medicine Humans education Motor skill lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 education.field_of_study Fetus business.industry Organophosphate Infant Newborn Infant Fetal Blood medicine.disease 030104 developmental biology chemistry Motor Skills Prenatal Exposure Delayed Effects Chlorpyrifos Cohort Female business |
| Zdroj: | Environment International, Vol 106, Iss, Pp 248-256 (2017) |
| ISSN: | 0160-4120 |
| Popis: | Background: Organophosphate insecticides (OPs) are used worldwide, yet despite nearly ubiquitous exposure in the general population, few have been studied outside the laboratory. Fetal brains undergo rapid growth and development, leaving them susceptible to long-term effects of neurotoxic OPs. The objective here was to investigate the extent to which prenatal exposure to OPs affects infant motor development. Methods: 30 OPs were measured in umbilical cord blood using gas chromatography tandem mass spectrometry in a cohort of Chinese infants. Motor function was assessed at 6-weeks and 9-months using Peabody Developmental Motor Scales 2nd edition (PDMS-2) (n=199). Outcomes included subtest scores: reflexes, stationary, locomotion, grasping, visual-motor integration (V-M), composite scores: gross (GM), fine (FM), total motor (TM), and standardized motor quotients: gross (GMQ), fine (FMQ), total motor (TMQ). Results: Naled, methamidophos, trichlorfon, chlorpyrifos, and phorate were detected in ≥10% of samples. Prenatal naled and chlorpyrifos were associated with decreased 9-month motor function. Scores were 0.55, 0.85, and 0.90 points lower per 1ng/mL increase in log-naled, for V-M (p=0.04), FM (p=0.04), and FMQ (p=0.08), respectively. For chlorpyrifos, scores were 0.50, 1.98, 0.80, 1.91, 3.49, 2.71, 6.29, 2.56, 2.04, and 2.59 points lower for exposed versus unexposed infants, for reflexes (p=0.04), locomotion (p=0.02), grasping (p=0.05), V-M (p |
| Databáze: | OpenAIRE |
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