In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977)
| Autor: | Yuko Yamaguchi, Masaya Takei, Ryuta Kishii |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology chemistry.chemical_classification biology Chemistry 030106 microbiology medicine.disease_cause Antimicrobial biology.organism_classification In vitro Microbiology 03 medical and health sciences Broad spectrum 030104 developmental biology Infectious Diseases Enzyme Susceptibility Staphylococcus aureus Streptococcus pneumoniae medicine Pharmacology (medical) Escherichia coli Bacteria |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 61 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00120-17 |
| Popis: | Lascufloxacin exhibited a broad spectrum of activity against various clinical isolates. Furthermore, lascufloxacin showed the most potent activity against Gram-positive bacteria among the quinolones tested and incomplete cross-resistance against existing quinolone-resistant strains. Enzymatic analysis indicated that lascufloxacin had potent inhibitory activity against both wild-type and mutated target enzymes. These results suggest that lascufloxacin may be useful in treating infections caused by various pathogens, including quinolone-resistant strains. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|