Genome of the Chinese tree shrew
| Autor: | Yuanxin Chen, Li Hu, Yabing Zhu, Ju-Min Zhou, Ceshi Chen, Ren Lai, Bin Liang, Zhiyong Huang, Yuyu Niu, Xuanting Jiang, Yong-Gang Yao, Jin Xiao, Dingding Fan, Xintian Hu, Chang-Chang Cao, Xudong Zhao, Dan Mu, Jinquan Xia, Wei Zhao, Xiaoqing Sun, Yongshan Lang, Guojie Zhang, Jing He, Shengguang Liao, Yu Fan, Yong-Tang Zheng, Lan Yang, Lin Xu, Yun Zhang, Zhiqiang Xiong, Yuanye Ma, Jun Wang, Haolong Hou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
China
General Physics and Astronomy Hepacivirus Nervous System Genome General Biochemistry Genetics and Molecular Biology Tree shrew Mice Tupaia belangeri Animal model Animals Humans Phylogeny Tupaia Whole genome sequencing Multidisciplinary biology Tupaia belangeri chinensis Genetic Variation Sequence Analysis DNA General Chemistry biology.organism_classification Hepatitis C Tree (data structure) Key factors Evolutionary biology Immune System Inactivation Metabolic |
| Zdroj: | Fan, Y, Huang, Z-Y, Cao, C-C, Chen, C-S, Chen, Y-X, Fan, D-D, He, J, Hou, H-L, Hu, L, Hu, X-T, Jiang, X-T, Lai, R, Lang, Y-S, Liang, B, Liao, S-G, Mu, D, Ma, Y-Y, Niu, Y-Y, Sun, X-Q, Xia, J-Q, Xiao, J, Xiong, Z-Q, Xu, L, Yang, L, Zhang, Y, Zhao, W, Zhao, X-D, Zheng, Y-T, Zhou, J-M, Zhu, Y-B, Zhang, G-J, Wang, J & Yao, Y-G 2013, ' Genome of the Chinese tree shrew ', Nature Communications, vol. 4, 1426 . https://doi.org/10.1038/ncomms2416 |
| DOI: | 10.1038/ncomms2416 |
| Popis: | Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few. Here we present a publicly available annotated genome sequence for the Chinese tree shrew. Phylogenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique features, and provide a genetic basis for the use of this animal as a potential model for biomedical research. The Chinese tree shrew, Tupaia belangeri chinensis, has been proposed as a potential animal model in biomedical research and drug safety testing. This study presents the full genome of the Chinese tree shrew, identifying common features between the tree shrew and primates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|