Severe Thrombotic Complications Associated with Activated Protein C Resistance Acquired by Orthotopic Liver Transplantation
| Autor: | Galina Pogrebijsky, Amiram Eldor, Shmuel Gillis, Avi Lebenthal, Ahmed Eid, Yizhar Levy |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment DNA Mutational Analysis Arterial Occlusive Diseases Liver transplantation Thrombophilia Gastroenterology Hepatic Artery Physiology (medical) Internal medicine medicine Factor V Leiden Humans Activated Protein C Resistance Venous Thrombosis biology business.industry Factor V Thrombosis Hematology medicine.disease Liver Transplantation Transplantation Mutation Immunology biology.protein Liver function Activated protein C resistance business Protein C medicine.drug |
| Zdroj: | Pathophysiology of Haemostasis and Thrombosis. 30:316-320 |
| ISSN: | 1424-8840 1424-8832 |
| DOI: | 10.1159/000054149 |
| Popis: | We report a patient who developed recurrent hepatic artery thrombosis and deep venous thrombosis following orthotopic liver transplantation. Investigations revealed the presence of activated protein C (APC) resistance due to a mutation in the factor V gene in the transplanted liver. The patient’s own peripheral blood cells did not carry the mutation. Although part of factor V is located in the platelets and may be endogenously synthesized by megakaryocytes, this case demonstrates the major clinical importance of hepatic-derived factor V. It may be reasonable to screen liver donors with a history of a thrombotic event for APC, and to consider anticoagulation in the recipients of livers positive for this defect. |
| Databáze: | OpenAIRE |
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