Levobunolol 0.5% and timolol 0.5% to prevent intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy
| Autor: | Alan I. Mandell, Sanford I. Rakofsky, Elaine P. Kelley, Theresa L. Iacono, Stuart A Terry, James D. Faulkner, Douglas D. Koch, Ronald L. Gross, John C. Lue |
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| Rok vydání: | 1997 |
| Předmět: |
Laser surgery
Adult Male medicine.medical_specialty Intraocular pressure genetic structures medicine.medical_treatment Premedication Adrenergic beta-Antagonists Levobunolol Lens Capsule Crystalline Timolol Ocular hypertension Glaucoma Cataract Double-Blind Method Ophthalmology medicine Humans Prospective Studies Posterior Capsulotomy Intraocular Pressure Aged Aged 80 and over business.industry Middle Aged medicine.disease eye diseases Sensory Systems Surgery Capsulotomy Female Ocular Hypertension sense organs Laser Therapy Ophthalmic Solutions business medicine.drug |
| Zdroj: | Journal of cataract and refractive surgery. 23(7) |
| ISSN: | 0886-3350 |
| Popis: | To evaluate the prophylactic effect of levobunolol 0.5%, timolol 0.5%, or vehicle in reducing the incidence of postoperative intraocular pressure (IOP) spikes of 5 and 10 mm Hg or more in patients having neodymium:YAG (Nd:YAG) laser posterior capsulotomy.Miami Vision Center, Coral Gables, Florida; Cullen Eye Institute, Baylor College of Medicine, Houston, Texas; Cincinnati Eye Institute, Cincinnati, Ohio; South Texas Cataract and Glaucoma Center, San Antonio, Texas; Mid-South Eye Foundation, Memphis, Tennessee, USA.This prospective, double-masked, randomized study comprised 144 patients having Nd:YAG laser posterior capsulotomy in one eye. One drop of the test medication was administered preoperatively and one drop on the evening after surgery; IOP was measured preoperatively and 1,2,3 and 24 hours postoperatively.Intraocular pressure elevations of 5 mm Hg or more were seen in 1 of 60 patients (2%) in the levobunolol group, 4 of 54 (7%) in the timolol group, and 10 of 28 (36%) in the vehicle group. These elevations occurred significantly more frequently in the vehicle group than in the levobunolol (P.001) or timolol (P.004) groups. Elevations of 10 mm Hg or more were found in 2 of 28 patients (7%) treated with vehicle but were not observed in the patients treated with levobunolol or timolol.Levobunolol 0.5% or timolol 0.5% administered preoperatively and again in the evening after Nd:YAG laser capsulotomy effectively blunted the IOP rise that frequently follows laser surgery. |
| Databáze: | OpenAIRE |
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