Intraperitoneal radiolabeled OC125 in patients with advanced ovarian cancer
| Autor: | Amin I. Kassis, Kevin Weadock, S S Tumeh, Robert C. Knapp, Vincent R. Zurawski, Michael G. Muto, Neil J. Finkler |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
medicine.medical_specialty Pathology endocrine system diseases Nausea medicine.medical_treatment Intraperitoneal injection Endometriosis Adenocarcinoma Gastroenterology Iodine Radioisotopes Mice White blood cell Internal medicine Animals Humans Medicine Euthyroid Aged Ovarian Neoplasms Platelet Count business.industry Thyroid Antibodies Monoclonal Obstetrics and Gynecology General Medicine Middle Aged Carcinoma Papillary Radiation therapy Diarrhea medicine.anatomical_structure Oncology Tumor progression Radioimmunotherapy Toxicity Erythrocyte Count Female medicine.symptom business Injections Intraperitoneal |
| Zdroj: | Gynecologic Oncology. 34:339-344 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/0090-8258(89)90169-8 |
| Popis: | Twenty patients with recurrent or persistent epithelial ovarian cancer failing conventional therapies were treated with a single intraperitoneal injection of iodine-131-labeled OC 125 monoclonal antibody. Rare acute side effects were nausea and mild diarrhea. At doses up to 120 mCi of iodine-131, median white blood cell and platelet count nadirs were 3.6k/microliters and 187k/microliters, respectively. Two patients acquired thyroid toxicities despite thyroid blockage with "cold" iodine. One patient had transient TSH elevation while remaining clinically euthyroid, and 1 patient developed activation of a thyroid nodule and clinical hyperthyroidism. Dose-limiting toxicity has not yet been observed. Twelve of 20 patients are alive 3 to 17 months following therapy. Tumor progression was noted in the majority of patients, although 3 patients had documented decreases in tumor burden of short duration. We conclude that, at the doses examined, iodine-131 OC 125 can be safely administered intraperitoneally. |
| Databáze: | OpenAIRE |
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