Meta-analysis of Seven Randomized Control Trials to Assess the Efficacy and Toxicity of Combining EGFR-TKI with Chemotherapy for Patients with Advanced NSCLC who Failed First-Line Treatment
| Autor: | Rong-qing Huang, Weilan Wang, Hai-Yan Si, Bing-Kun Xiao, Jian-Yun Yang, Zhao-Shuai Ji, Jun-xing Dong |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Combination therapy Epidemiology medicine.medical_treatment Antineoplastic Agents Disease-Free Survival law.invention Randomized controlled trial law Carcinoma Non-Small-Cell Lung Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Protein Kinase Inhibitors Aged Randomized Controlled Trials as Topic Chemotherapy business.industry Public Health Environmental and Occupational Health Middle Aged Prognosis respiratory tract diseases Surgery ErbB Receptors Clinical trial Regimen Pemetrexed Docetaxel Meta-analysis Female business medicine.drug |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:2915-2921 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2015.16.7.2915 |
| Popis: | Background: Some recent clinical trials have been conducted to evaluate a combination of EGFR- TKI with chemotherapy for advanced NSCLC patients as second-line therapy, but the results on the efficacy of such trials are inconsistent. The aim of this meta-analysis was to evaluate the efficacy and safety of combination of EGFR-TKI and chemotherapy for patients with advanced NSCLC who failed first-line treatment. Materials and Methods: We searched relative trials from PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, Cochrane Library and Clinical Trials.gov. Outcomes analyzed were overall response rate (ORR), progression- free survival (PFS), overall survival (OS) and major toxicity. Results: Seven trails eventually were included in this meta-analysis, covering 1,168 patients. The results showed that the combined regimen arm had a significant higher ORR (RR 1.76 [1.16, 2.66], p=0.007) and longer PFS (HR 0.75 [0.66-0.85], p |
| Databáze: | OpenAIRE |
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