A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
| Autor: | Molly A Williams, Amanda B. Nymon, Deepika Polineni, Jianghua He, Alex H. Gifford, Theodore Budden, Akshu Balwan, Jessica L D'Amico, Jonathan B. Zuckerman, Dana B. Dorman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Treatment response medicine.medical_specialty Cystic Fibrosis Exacerbation Science Iron Pilot Projects Inflammation Gastroenterology Cystic fibrosis Article Young Adult 03 medical and health sciences Medical research 0302 clinical medicine Internal medicine medicine Humans Prospective Studies Signs and symptoms Pulmonary exacerbation Multidisciplinary business.industry Iron levels Sputum Middle Aged Symptom Flare Up medicine.disease Phenotype Anti-Bacterial Agents Treatment Outcome 030104 developmental biology 030228 respiratory system Medicine Female medicine.symptom business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-84041-y |
| Popis: | The cystic fibrosis (CF) community seeks to explain heterogeneous outcomes of pulmonary exacerbation (PEX) treatment. Serum and sputum inflammatory mediators may identify people with CF (PwCF) at risk for suboptimal responses. However, lack of an established association between response phenotypes and these mediators limits clinical application. In this pilot study, we prospectively characterized treatment response phenotypes by assessing health-related quality-of-life (HRQoL) during PEX. We also measured lung function and iron-related biochemical parameters in serum and sputum. We classified subjects as sustained symptom-responders (SRs) or non-sustained symptom-responders (NSRs) based on the absence or presence, respectively, of worsened symptom scores after initial improvement. We used linear mixed models (LMMs) to determine whether trends in lung function, hematologic, serum, and sputum indices of inflammation differed between response cohorts. In 20 PwCF, we identified 10 SRs and 10 NSRs with no significant differences in lung function at PEX onset and treatment durations. SRs had better model-predicted trends in lung function than NSRs during PEX. Non-linear trends in serum and sputum iron levels significantly differed between SRs and NSRs. In adults with cystic fibrosis, PEX treatment response phenotypes may be correlated with distinctive trends in serum and sputum iron concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink