Changes in renal dimensions evaluated by magnetic resonance imaging and ultrasonography during long-term ciclosporin-a treatment
| Autor: | Jens Tølbøll Mortensen, Hans Erik Hansen, M. Madsen, H. Kaalund, Michael Pedersen, Donata Cibulskyte, Hanefelt D. Kristensen, M. C. Grøn, Arne Hørlyck |
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| Rok vydání: | 2006 |
| Předmět: |
Swine
In Vitro Techniques Renal length Kidney Time medicine Animals Radiology Nuclear Medicine and imaging Ultrasonography Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Magnetic resonance imaging Organ Size General Medicine Ciclosporin Magnetic Resonance Imaging medicine.anatomical_structure Cyclosporine Swine Miniature business Nuclear medicine Immunosuppressive Agents medicine.drug |
| Zdroj: | Grøn, M, Kristensen, D H, Cibulskyte, D, Hørlyck, A, Kaalund, H, Hansen, H E, Madsen, M, Pedersen, M & Mortensen, J 2006, ' Changes in renal dimensions evaluated by magnetic resonance imaging and ultrasonography during long-term ciclosporin-A treatment ', Acta Radiol., vol. 47, pp. 58-64 . Hansen, H E, Madsen, M, Grøn, M C, Kristensen, D H, Cibulskyte, D, Hørlyck, A, Kaalund, H, Pedersen, M & Mortensen, J 2005, ' Changes in Renal Dimensions Evaluated by Magnetic Resonance Imaging and Ultrasonography During Long-term Ciclosporin-A Treatment. ', Acta Radiologica, vol. 47, pp. 58-64 . |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1080/02841850500406829 |
| Popis: | Purpose: To investigate changes in renal dimensions during long-term treatment with ciclosporin-A (CsA). Material and Methods: Five mini-Göttingen pigs were treated with CsA (10 mg kg−1day−1) for 6 months; 3 untreated animals served as controls. Renal length was measured by magnetic resonance imaging (MRI) and ultrasonography (US); renal volume by MRI. Examinations were performed at baseline (0 weeks) and after the start of CsA treatment at intervals of 5 weeks (5–25 weeks). Results: Comparison of baseline and end-point data (0 weeks vs. 25 weeks) revealed a statistically significant increase in renal volume in CsA-treated animals (87.1 cm3 vs. 55.9 cm3, P = 0.002). Renal volume remained unchanged in the control group. A significant increase in renal length was found both in the CsA-treated pigs (MRI: 96 mm vs. 84 mm, P Conclusion: During long-term CsA treatment, renal volume increases in mini-pigs, but there is no correlation between the increase in volume and the increase in length in this pig model. |
| Databáze: | OpenAIRE |
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