Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
| Autor: | Ricardo José Nunes, Claudio Cesar Cirne-Santos, Tomas Bergström, Jadel M. Kratz, Cláudia Maria Oliveira Simões, Rosendo A. Yunes, Edward Trybala, Célia Regina Monte Barardi, Deise Juliana Kolling, Paulo César Leal, Izabel C.P.P. Frugulhetti, Carla Regina Andrighetti-Fröhner |
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| Předmět: |
Microbiology (medical)
Anti hiv 1 Pentyl gallate lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Anti-HIV Agents viruses lcsh:QR1-502 Herpesvirus 1 Human medicine.disease_cause Virus Replication Antiviral Agents lcsh:Microbiology Virus chemistry.chemical_compound Gallic Acid Chlorocebus aethiops medicine Animals Humans Gallic acid Mode of action Vero Cells pentyl gallate antiviral HSV-1 Anti hsv 1 Herpes simplex virus Biochemistry chemistry Vero cell HIV-1 Leukocytes Mononuclear Cattle gallic acid |
| Zdroj: | ResearcherID Memórias do Instituto Oswaldo Cruz., Vol 103, Iss 5, Pp 437-442 (2008) Memórias do Instituto Oswaldo Cruz, Volume: 103, Issue: 5, Pages: 437-442, Published: AUG 2008 |
| Popis: | The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited. |
| Databáze: | OpenAIRE |
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