Predictors for acute and chronic pouchitis following restorative proctocolectomy for ulcerative colitis
| Autor: | Jonathan N. Lund, N. Kandiyil, Ayman S. Abdelrazeq, J. R. Reynolds, I. D. Botterill, P. J. Holdsworth, Stephen H. Leveson |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Pouchitis Severity of Illness Index Gastroenterology Statistics Nonparametric Primary sclerosing cholangitis Cohort Studies Young Adult Age Distribution Predictive Value of Tests Internal medicine Odds Ratio Prevalence medicine Humans Cumulative incidence Sex Distribution Probability Retrospective Studies First episode Analysis of Variance Univariate analysis Proctocolectomy business.industry Incidence (epidemiology) Proctocolectomy Restorative Middle Aged medicine.disease Ulcerative colitis Acute Disease Chronic Disease Quality of Life Colitis Ulcerative Female business Follow-Up Studies |
| Zdroj: | Colorectal Disease. 10:805-813 |
| ISSN: | 1463-1318 1462-8910 |
| Popis: | Objective This study was undertaken to evaluate the cumulative incidence, onset and risk predicting factors for acute and chronic pouchitis. Method A consecutive series of patients (n = 210), who underwent restorative proctocolectomy (RPC) and had a minimum follow-up of 12 months was reviewed. The cumulative incidence and onset of pouchitis was determined. Univariate analysis, followed by logistic regression analysis was used to evaluate the association of various demographic, clinical and histopathologic variables with the subsequent development of acute and chronic pouchitis. Results A total of 198 patients were included. The mean follow-up was 64 months (range, 12–180). Sixty-four patients (32%) developed pouchitis, 35 acute and 29 chronic. The first episode of pouchitis occurred within the first year in 70% of cases. The presence of backwash ileitis (OR, 2.6; P = 0.015), primary sclerosing cholangitis (PSC; OR, 2; P = 0.018) and the duration of follow-up (OR, 1.1; P = 0.043) were associated with a higher incidence of pouchitis. The duration of follow-up was the only variable associated with acute pouchitis (P = 0.007). The presence of backwash ileitis and PSC were independent risk factors for chronic pouchitis (OR, 5.9; P |
| Databáze: | OpenAIRE |
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