Blockade of adenosine A1 receptors in the posterior cingulate cortex facilitates memory in rats
| Autor: | Cristina Rodrigues, Ana Maria Oliveira Battastini, Humberto Kukhyun Choi, Tadeu Mello e Souza, João José Freitas Sarkis, Elsa Regina do Canto Vinade, Carla Denise Bonan, Grace S. Pereira, Ivan Izquierdo |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Agonist Cingulate cortex Adenosine medicine.drug_class Pharmacology cingulate cortex Gyrus Cinguli Adenosine A1 receptor Memory Cortex (anatomy) Avoidance Learning medicine Animals adenosine A1 receptors Dose-Response Relationship Drug Long-term memory business.industry Receptors Purinergic P1 Retention Psychology Rats medicine.anatomical_structure Purinergic P1 Receptor Antagonists adenosine Xanthines Posterior cingulate Memory consolidation business Neuroscience medicine.drug |
| Zdroj: | Repositório Institucional PUCRS Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
| ISSN: | 0014-2999 |
| Popis: | Male Wistar rats were bilaterally implanted with indwelling cannulae in the caudal region of the posterior cingulate cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA foot shock) and received, immediately after training, a 0.5-μl infusion of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA; 1, 50 or 100 nM) or of the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1, 25 or 50 nM). Animals were tested twice, 1.5 h and, again, 24 h after training, in order to examine the effects of these agents on short- and long-term memory, respectively. Only 50-nM DPCPX was effective in altering memory, promoting a facilitation. These results suggest that adenosine A1 receptors in the posterior cingulate cortex inhibit memory consolidation in a way that their blockade facilitates memory for inhibitory avoidance in rats. |
| Databáze: | OpenAIRE |
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