Gonadal Steroids Negatively Modulate Oxidative Stress in CBA/Ca Female Mice Infected with P. berghei ANKA
| Autor: | Fidel Orlando Buendía-González, Ana Laura Rodríguez-Morales, Jorge Morales-Montor, Néstor Aarón Mosqueda-Romo, Margarita Aguilar-Sánchez, Martha Legorreta-Herrera |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Article Subject Plasmodium berghei lcsh:Medicine Spleen Nitric Oxide medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology Nitric oxide Superoxide dismutase Mice chemistry.chemical_compound Internal medicine parasitic diseases medicine Animals Gonadal Steroid Hormones Gonads chemistry.chemical_classification General Immunology and Microbiology biology Glutathione peroxidase Body Weight lcsh:R Anemia General Medicine biology.organism_classification Malaria Sexual dimorphism Oxidative Stress Endocrinology medicine.anatomical_structure chemistry Catalase Mice Inbred CBA biology.protein Female Oxidative stress Research Article |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | We decreased the level of gonadal steroids in female and male mice by gonadectomy. We infected these mice withP. bergheiANKA and observed the subsequent impact on the oxidative stress response. Intact females developed lower levels of parasitaemia and lost weight faster than intact males. Gonadectomised female mice displayed increased levels of parasitaemia, increased body mass, and increased anaemia compared with their male counterparts. In addition, gonadectomised females exhibited lower specific catalase, superoxide dismutase, and glutathione peroxidase activities in their blood and spleen tissues compared with gonadectomised males. To further study the oxidative stress response inP. bergheiANKA-infected gonadectomised mice, nitric oxide levels were assessed in the blood and spleen, and MDA levels were assessed in the spleen. Intact, sham-operated, and gonadectomised female mice exhibited higher levels of nitric oxide in the blood and spleen compared with male mice. MDA levels were higher in all of the female groups. Finally, gonadectomy significantly increased the oxidative stress levels in females but not in males. These data suggest that differential oxidative stress is influenced by oestrogens that may contribute to sexual dimorphism in malaria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|