Inhibition of G1 Cyclin Expression and G1 Cyclin-Dependent Protein-Kinases by cAMP in an Astrocytic Cell Line
| Autor: | D. Toru-Delbauffe, Claire Gagelin, Michel Pierre |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cyclin D
Cyclin A Biophysics Cyclin B Protein Serine-Threonine Kinases Biochemistry Cell Line Cyclin-dependent kinase Cyclins CDC2-CDC28 Kinases Cyclic AMP Molecular Biology Mitogen-Activated Protein Kinase 1 biology Chemistry Cyclin-Dependent Kinase 2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 3 Cell Biology Protein-Tyrosine Kinases Immunohistochemistry Cyclin-Dependent Kinases Cell biology Enzyme Activation Kinetics Astrocytes biology.protein Cancer research Cyclin-dependent kinase complex Cell Division Cyclin A2 |
| Zdroj: | Biochemical and Biophysical Research Communications. 205:923-929 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1994.2753 |
| Popis: | The effects of cAMP on cell cycle progression were examined using an astrocytic cell line. We show that forskolin and 8-bromo-cAMP block the basic Fibroblast Growth Factor-induced DNA synthesis, do not inhibit mitogen activated protein kinase activation whereas they reduce G1 cyclin (E and D1) expression without modification of cyclin A level. Furthermore, they inhibit the activation of cyclin A- and cyclin E-dependent histone H1 kinases. These results suggest that cAMP may exert its antiproliferative effects through the regulation of cyclin synthesis and cyclin-dependent kinase activation. |
| Databáze: | OpenAIRE |
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